研究人员开发药物RI-AG03,针对阿尔茨海默氏症相关Tau蛋白,延长果蝇寿命,减少人类细胞神经元退化。 Researchers develop drug RI-AG03 targeting Alzheimer's-linked tau proteins, extending fruit fly lifespan and reducing neuron degeneration in human cells.

研究者开发了一种有前途的药物RI-AG03,针对与阿尔茨海默氏病有关的Tau蛋白质上的“热点”。 Researchers have developed a promising drug, RI-AG03, which targets specific 'hotspots' on tau proteins linked to Alzheimer's disease. 在对果蝇的试验中,RI-AG03将其寿命延长了35%,减少了人体细胞神经元退化。 In tests on fruit flies, RI-AG03 extended their lifespan by 35% and reduced neuron degeneration in human cells. 这种抑制剂的双向机制可能导致神经退行性疾病的更有效的治疗方法. This peptide inhibitor's dual-targeting mechanism may lead to more effective treatments for neurodegenerative diseases. 今后的步骤包括对小鼠进行测试,并转向临床试验。 Next steps involve testing on mice and moving to clinical trials.