研究人员开发了一种有效的MED6-189药物,对抗药物敏感和耐药的疟疾寄生虫,破坏了虫细胞和囊泡贩运通路. Researchers develop drug MED6-189 effective against drug-sensitive and resistant malaria parasites, disrupting apicoplast and vesicular trafficking pathways.
来自UC Riverside、UC Irvine和耶鲁的研究人员创造了一种新的药物MED6-189,既能有效对付对药物敏感又耐药的疟疾寄生虫恶性疟原虫病菌株。 Researchers from UC Riverside, UC Irvine, and Yale have created a new drug, MED6-189, effective against both drug-sensitive and resistant strains of the malaria parasite Plasmodium falciparum. 通过破坏寄生虫中的蜂细胞和囊泡运输通路,该药物可以防止抗药性发展. By disrupting the apicoplast and vesicular trafficking pathways in the parasite, the drug prevents resistance development. 在对人性化小鼠和猴子的试验中,发现了有希望的结果。 Promising results were seen in tests on humanized mice and monkeys. 计划进一步优化和探索毒品机制。 Further optimization and exploration of the drug's mechanisms are planned.