澳大利亚研究人员创建了胆固醇基药物运载系统,使寄生虫治疗药物效力提高3-25倍。 Australian researchers create cholesterol-based drug delivery system, enhancing parasite-treating drug effectiveness by 3-25 times.
ANU的澳大利亚研究人员开发了一种基于胆固醇的“Trojan马”方法,将胆固醇附在药物上,利用寄生虫对胆固醇的需求生存。 Australian researchers from ANU have developed a cholesterol-based "Trojan horse" method that attaches cholesterol to drugs, exploiting parasites' need for cholesterol to survive. 这使这些药物能够进入寄生虫的系统并产生致命效果,使治疗疟疾、利什曼病、长效虫病和牲畜寄生虫等疾病的疗效提高3至25倍。 This allows the drugs to enter the parasite's system and exert their killing effect, making treatments for diseases like malaria, leishmaniasis, giardia, and livestock parasites 3-25 times more effective. 这种办法还可以帮助重新使用多余的疟疾药物,节省数十亿农业损失,并为随行动物和牲畜提供新的治疗。 This approach could also help repurpose redundant malaria drugs, save billions in agricultural losses, and provide new therapies for companion animals and livestock.