圣地亚哥哥伦比亚大学的研究人员开发了新的方法,以创造稳定的圆环RNA分子,提高RNA治疗潜力。 Researchers at UC San Diego developed new methods to create stable circular RNA molecules, improving RNA therapy potential.

加利福尼亚圣地亚哥大学的研究人员开发了两种新方法,以创造稳定的圆环RNA分子,这可能导致更有效和更持久的RNA疗法。 Researchers at the University of California San Diego have developed two new methods to create stable circular RNA (cRNA) molecules, which could lead to more effective and long-lasting RNA therapies. 圆环RNA具有闭环结构,比线性RNA更耐降解,并在心脏肌肉细胞和神经元中进行了测试,显示稳定性和生物活动增强。 Circular RNAs, with a closed-loop structure, are more resistant to degradation than linear RNAs and were tested in heart muscle cells and neurons, displaying enhanced stability and biological activity. 新的方法涉及RtcB蛋白或细菌酶组II异子体,比以前的方法简单,可伸缩,今后的研究将调查这些方法在其他活体环境中的应用情况。 The new methods, involving RtcB protein or bacterial enzyme group II introns, are simpler and more scalable than previous methods, and future studies will investigate their application in other in vivo settings.