修改后的脂质纳米颗粒更有效地将mRNA疫苗传递到淋巴结,减少肝脏积累. Modified lipid nanoparticles deliver mRNA vaccines to lymph nodes more effectively, reducing liver accumulation.

宾夕法尼亚大学的工程师开发了改造后的脂质纳米粒子,可以更有效地将mRNA疫苗送到淋巴结中,同时减少肝脏积累. Penn engineers have developed modified lipid nanoparticles that deliver mRNA vaccines more effectively to lymph nodes while reducing liver accumulation. 在动物模型中,这些aroLNP保持强烈的免疫反应,同时向肝脏输送mRNA至少比Moderna疫苗配方少十倍,这可能使剂量更低和副作用更少. In animal models, these aroLNPs maintained strong immune responses while delivering at least tenfold less mRNA to the liver than the Moderna vaccine formulation, potentially allowing for lower doses and fewer side effects. 这项技术可以改善未来的mRNA治疗癌症和自身免疫性疾病. This technology could improve future mRNA therapies for cancer and autoimmune diseases.