细胞感觉到组织僵硬 高达100微米的距离, 帮助发育 和癌症传播, 这一发现 可能导致新的 抗转移治疗。 Cells sense tissue stiffness up to 100 microns away, aiding development and cancer spread, a discovery that may lead to new anti-metastasis treatments.

圣路易斯华盛顿大学的一项新研究显示,人类细胞,包括癌症细胞,通过拉动外细胞基体中的钴纤维,可以感知身体特性,如组织中的僵硬性,远远超出直接接触范围。 A new study from Washington University in St. Louis reveals that human cells, including cancer cells, can sense physical properties like stiffness in tissues far beyond their immediate contact by pulling on collagen fibers in the extracellular matrix. 癌症细胞可以探测到前方多达10微米的条件,而正常的上皮细胞小组一起工作可以感知到多达100微米的距离。 Cancer cells can detect conditions up to 10 microns ahead, while groups of normal epithelial cells working together can sense up to 100 microns away. 这种深度机械遥感有助于引导细胞在发育、愈合和癌症传播过程中的运动。 This depth mechano-sensing helps guide cell movement during development, healing, and cancer spread. PNAS中公布的调查结果表明,破坏这种能力可能会为限制癌症转移提供新的途径。 The findings, published in PNAS, suggest that disrupting this ability could offer new ways to limit cancer metastasis.