使用HCW9206的新的CAR-T方法刺激T细胞寿命,防治小鼠中的白血病和艾滋病毒,为持久癌症缓解和艾滋病毒治愈提供希望。 A new CAR-T method using HCW9206 boosts T cell longevity and fights leukemia and HIV in mice, offering hope for lasting cancer remissions and an HIV cure.

一种新的CAR-T细胞制造方法,使用工程制造的蛋白质手架HCW9206,结合三种免疫信号蛋白,生产T记忆干细胞,提高寿命和自我更新。 A new CAR-T cell manufacturing method using an engineered protein scaffold, HCW9206, combines three immune-signaling proteins to produce T memory stem cells with enhanced longevity and self-renewal. 在鼠类模型中,这些细胞显示在防治白血病和艾滋病毒、防止复发和减少病毒储存方面开展了更有力、更持续的活动。 In mouse models, these cells showed stronger, sustained activity against leukemia and HIV, preventing relapse and reducing viral reservoirs. 由艾伯特·爱因斯坦医学研究学院开发的这一方法可导致癌症患者长期康复,并使研究人员更接近于治疗艾滋病毒的功能,尽管它仍在临床前测试中。 The approach, developed by Albert Einstein College of Medicine researchers, could lead to longer-lasting remissions in cancer patients and bring researchers closer to a functional cure for HIV, though it remains in preclinical testing.