哥伦比亚研究人员创造了一种极小的侵入性RNA疗法,在心脏病发作后帮助修复心脏,通过重新规划肌肉来生产心脏再生蛋白质,在动物研究中显示出希望。 Columbia researchers created a minimally invasive RNA therapy that helps hearts repair after a heart attack by reprogramming muscle to produce heart-regenerating proteins, showing promise in animal studies.

由哥伦比亚大学领导的团队开发了RNA疗法, 在心脏病发作后, A Columbia University-led team has developed an RNA therapy that boosts the heart’s natural repair after a heart attack using a single injection. 治疗程序重新编程骨骼肌肉以产生亲ANP,一种先质被心脏丰富的Corin酶活化为甲状腺激素(ANP)。 The treatment reprograms skeletal muscle to produce pro-ANP, a precursor activated into atrial natriuretic peptide (ANP) by the heart’s abundant Corin enzyme. 在动物研究中,它减少了疤痕,改善了心脏功能,并促进了血管生长-模仿新生儿的再生能力。 In animal studies, it reduced scarring, improved heart function, and promoted blood vessel growth—mimicking newborns’ regenerative ability. 与侵入性程序不同的是,它极低的侵入性、可负担性,而且具体针对心脏。 Unlike invasive procedures, it’s minimally invasive, affordable, and targets the heart specifically. 2026年3月5日发表于Science 2026, 该方法为治疗心脏损伤提供了一条有希望的新途径,等待进一步的人类试验。 Published in Science on March 5, 2026, the approach offers a promising new path for treating heart damage, pending further human trials.