哥伦比亚研究人员创建了超敏感的CAR T细胞,通过针对低水平CD70, 消灭小鼠的固态肿瘤,为难以治疗的癌症带来希望。 Columbia researchers created super-sensitive CAR T cells that wiped out solid tumors in mice by targeting low-level CD70, offering hope for hard-to-treat cancers.

哥伦比亚大学的研究人员开发了超敏感CART细胞,称为HIT受体,以CD70为目标,成功地根除了小鼠的肾脏、卵巢和胰腺肿瘤。 CD70是固态肿瘤细胞中一种极低水平的蛋白质。 Researchers at Columbia University have developed ultra-sensitive CAR T cells, called HIT receptors, that successfully eradicated kidney, ovarian, and pancreatic tumors in mice by targeting CD70, a protein present at very low levels on solid tumor cells. 与常规的CAR T细胞不同,这些工程设计的细胞检测到最小的CD70表达式,使其能够消除以前遗漏的癌症细胞,包括被认为CD70负值的细胞。 Unlike conventional CAR T cells, these engineered cells detect minimal CD70 expression, enabling them to eliminate cancer cells previously missed, including those deemed CD70-negative. 这种疗法为健康组织留出了余地,显示出治疗一系列耐现有免疫疗法的固态肿瘤的前景。 The therapy, which spares healthy tissues, shows promise for treating a range of solid tumors resistant to current immunotherapies. 该小组计划为人类试验寻求资金,可能用于近20种癌症。 The team plans to seek funding for human trials, with potential applications in nearly 20 cancer types.