一项新研究发现,有病的脂质纳米粒子比紧身包装的纳米粒子能更有效地提供 mRNA。 Disordered lipid nanoparticles deliver mRNA more effectively than tightly packed ones, a new study finds.

哥本哈根大学的一项新研究发现,用于MRNA疫苗和疗法的脂质纳米粒子(LNPs),当内部组织混乱而不是包装严密时,可以更有效地运送货物。 A new study from the University of Copenhagen finds that lipid nanoparticles (LNPs), used in mRNA vaccines and therapies, deliver their cargo more effectively when internally disorganized rather than tightly packed. 研究人员一次分析了多达一百万个粒子, 发现无形,结构较差的LNP在细胞内释放它们的RNA更有效, Analyzing up to a million particles at a time, researchers discovered that amorphous, less structured LNPs release their RNA more efficiently inside cells due to charge repulsion breaking them apart under cellular conditions. 这挑战了人们长期以来的信念,即最大的货物包装和订单能够改善交货情况。 This challenges the long-held belief that maximum cargo packing and order improve delivery. 预定在2026年2月举行的生物物理社会年度会议上提出的研究结果表明,优化对受控内乱的治疗可以加强癌症和遗传病的治疗。 The findings, set to be presented at the Biophysical Society Annual Meeting in February 2026, suggest that optimizing for controlled internal disorder could enhance treatments for cancer and genetic disorders.