猫和人类分享关键的癌症基因,通过研究发现类似的肿瘤突变和治疗反应,为两者推广精密药物。 Cats and humans share key cancer genes, with study revealing similar tumor mutations and treatment responses, advancing precision medicine for both.

对五个国家近500只猫进行的大规模研究发现,胎儿癌和人类癌症之间在遗传上有很强的相似性,特别是在TP53、FBXW7和PIK3CA等基因方面,这些基因与人体侵袭性乳腺癌和其他癌症有关。 A large-scale study of nearly 500 cats across five countries has found strong genetic similarities between feline and human cancers, particularly in genes like TP53, FBXW7, and PIK3CA, which are linked to aggressive breast and other cancers in humans. 研究人员发现13种瘤类型中共享的突变,包括乳腺,血液和皮肤癌,猫瘤在遗传学和治疗反应方面都反映了人类的模式. Researchers identified shared mutations in 13 tumor types, including mammary, blood, and skin cancers, with feline tumors mirroring human patterns in both genetics and treatment response. 这些结论是“一个医学”方法的一部分,它建议猫——由于共同的环境和自发的肿瘤发育——为发展有针对性的疗法提供宝贵的见解,某些化疗药物在带有特定突变的肿瘤中显示出更好的效果。 The findings, part of the "One Medicine" approach, suggest cats—due to shared environments and spontaneous tumor development—offer valuable insights for developing targeted therapies, with certain chemotherapy drugs showing better results in tumors with specific mutations. 这项研究建立了一个公开的数据库,标志着朝向推进两种物种的精密医学迈出了一大步。 The study, which created a publicly available database, marks a major step toward advancing precision medicine for both species.