一种罕见的基因突变导致疫苗诱发的血凝块 通过触发抗体来攻击人类蛋白质 新的研究发现 A rare genetic mutation causes vaccine-induced blood clots by triggering antibodies to attack a human protein, new research finds.

一个全球研究小组查明了与基于乙型病毒的COVID-19疫苗相关联的罕见血液凝聚障碍VIT的原因:一些人的罕见基因突变导致抗体错误地攻击人体血蛋白PF4(PF4),其原因是疫苗中分子模仿了病毒蛋白。 A global research team has identified the cause of the rare blood clotting disorder VITT linked to adenovirus-based COVID-19 vaccines: a rare genetic mutation in some individuals causes antibodies to mistakenly attack a human blood protein, PF4, due to molecular mimicry with a viral protein in the vaccine. 在《新英格兰医学杂志》上发表的这一发现解释了为什么VITT大约每100 000名接受者中有2名接受者出现,并为重新设计疫苗提供了一条明确的道路,即通过修改安地诺病毒病媒来消除风险,同时保持有效性。 The discovery, published in the New England Journal of Medicine, explains why VITT occurs in about two per 100,000 recipients and offers a clear path to redesign vaccines by modifying the adenovirus vector to eliminate the risk while preserving effectiveness.