据圣母院研究人员说,肿瘤不仅通过侵入组织造成脑损伤,而且通过对神经元施压、引发细胞死亡和炎症造成脑损伤。 Tumors cause brain damage not just by invading tissue, but by pressing on neurons, triggering cell death and inflammation, according to Notre Dame researchers.

基因瘤等肿瘤造成的慢性脑压力触发神经元启动自毁程序,导致不可逆转的损伤和神经衰落。 Chronic brain pressure from tumors like glioblastoma triggers neurons to activate self-destruction programs, leading to irreversible damage and neurological decline. 圣母大学的研究人员利用干细胞派生脑模型表明,持续压缩导致神经和螺旋细胞死亡,同时压力和发炎标志HIF-1和AP-1增加,病人中也出现变化。 Researchers at the University of Notre Dame used stem cell-derived brain models to show that sustained compression causes neuron and glial cell death, along with increased levels of stress and inflammation markers HIF-1 and AP-1—changes also seen in patients. 这些调查结果表明,机械力量大大促进了脑功能失调,超出了直接肿瘤入侵的范围,为治疗提供了新的目标,以保护脑肿瘤中的神经元,以及涉及大脑身体压力的其他状况。 These findings indicate mechanical forces contribute significantly to brain dysfunction beyond direct tumor invasion, offering new targets for therapies to protect neurons in brain tumors and other conditions involving physical stress on the brain.