俄勒冈州研究人员发明了一种铁基纳米材料,用双重活性氧物种杀死小鼠的乳腺癌,没有毒性或复发性。 Oregon State researchers created an iron-based nanomaterial that kills breast cancer in mice using dual reactive oxygen species, with no toxicity or recurrence.

俄勒冈州立大学的研究人员开发了一种铁基纳米材料,通过在肿瘤中生成氢氧基和单氧,利用癌症细胞的酸性、高过氧化环境,杀死癌症细胞。 Researchers at Oregon State University have developed an iron-based nanomaterial that kills cancer cells by generating both hydroxyl radicals and singlet oxygen within tumors, exploiting the acidic, high-peroxide environment of cancer cells. 作为化学动力学疗法一部分的双重行动方法在实验室和老鼠模型中显示出很强的效力,完全消除人类乳腺癌,不发生重复或不产生毒性。 The dual-action approach, part of chemodynamic therapy, showed strong effectiveness in lab and mouse models, eliminating human breast tumors completely with no recurrence or toxicity. 纳米剂通过以更高的效率生产两种活性氧物种,优于以往的处理方式。 The nanoagent outperformed previous treatments by producing both reactive oxygen species with higher efficiency. 该小组计划对其他癌症进行测试,包括胰腺癌。 The team plans to test it against other cancers, including pancreatic cancer. 该研究报告由国家卫生研究所资助,发表在《高级功能材料》中。 The study, funded by the NIH, was published in Advanced Functional Materials.