科学家发现了一种脑免疫心脏路径 使小鼠的心脏病发作恶化 暗示了新的治疗可能性 Scientists found a brain-immune-heart pathway that worsens heart attacks in mice, suggesting new treatment possibilities.

San Diego CUC的科学家已经确定了一种脑免疫心脏路径,它使小鼠心脏病发作的损伤恶化,表明TRPV1表达式的 vagus神经神经元通过一个涉及下丘脑的电路触发炎症。 Scientists at UC San Diego have identified a brain-immune-heart pathway that worsens heart attack damage in mice, showing that TRPV1-expressing vagus nerve neurons trigger inflammation through a circuit involving the hypothalamus. 通过静默神经元、针对大脑、或阻止免疫反应——显著改善心脏功能、减少组织损伤和稳定电动活动,干扰神经循环的任何部分。 Disrupting any part of this neural loop—by silencing neurons, targeting the brain, or blocking immune responses—significantly improved heart function, reduced tissue damage, and stabilized electrical activity. 在细胞中公布的研究结果揭示了大脑在扩大心脏伤害方面的积极作用,并表明已经用于自发免疫疾病的现有 vagus神经刺激器可以被重新用于心脏病发作治疗。 The findings, published in Cell, reveal the brain’s active role in amplifying heart injury and suggest that existing vagus nerve stimulators, already used for autoimmune diseases, could be repurposed for heart attack therapy. 虽然人类应用已经多年了,但研究标志着一种转变,即将神经和免疫系统理解为心血管健康的核心。 While human applications are years away, the study marks a shift toward understanding the nervous and immune systems as central to cardiovascular health.