基因疗法 恢复Connexin-43 改善心脏功能和生存 在小鼠的心脏功能和生存 有罕见的,致命的心脏病症。 Gene therapy restoring connexin-43 improved heart function and survival in mice with a rare, deadly heart condition.

UC San Diego领导的一项研究表明,恢复Connexin-43的基因疗法可以改善心功能,改善心血管心血管病(ACM)小鼠的存活能力,这是与年轻运动员突然心脏死亡有关的罕见的遗传心脏病病。 A UC San Diego-led study shows gene therapy restoring connexin-43 improves heart function and survival in mice with arrhythmogenic cardiomyopathy (ACM), a rare genetic heart condition linked to sudden cardiac death in young athletes. 治疗,通过病毒病媒提供,增强电信号,减少心律失常,修复心脏结构,即使是在先进的病例中也是如此。 The treatment, delivered via viral vector, enhanced electrical signaling, reduced arrhythmias, and repaired heart structure, even in advanced cases. 研究人员发现Connexin-43还可能影响细胞核中的基因活动,表明治疗潜力更大。 Researchers found connexin-43 may also influence gene activity in the cell nucleus, suggesting broader therapeutic potential. 虽然尚未计划对人类进行试验,但这种方法有一天可以治疗多种ACM类型,而不考虑特定的基因突变. While human trials are not yet planned, the approach could one day treat multiple ACM types regardless of specific genetic mutation. 研究结果于2026年1月26日公布。 The findings were published January 26, 2026.