一项试验发现,在抗雌性激素疗法中增加了低剂量药物剂,减缓了绝经期后患有ER阳性乳腺癌的妇女的肿瘤增长。 A trial found adding low-dose megestrol to anti-estrogen therapy slowed tumor growth in post-menopausal women with ER-positive breast cancer.

由剑桥牵头的一项试验发现,在抗蛋白治疗中添加低剂量药物乙酸乙酯,即合成原孕酮,减缓了患有ER-阳性乳腺癌的绝经期后妇女肿瘤的增长。 A Cambridge-led trial found that adding low-dose megestrol acetate, a synthetic progesterone, to anti-estrogen therapy slowed tumor growth in post-menopausal women with ER-positive breast cancer. 在PIONEER研究中,接受综合治疗的198名病人的肿瘤生长下降幅度大于仅进行抗原治疗的病人。 In the PIONEER study, 198 patients receiving the combination treatment showed greater reductions in tumor growth than those on anti-estrogen therapy alone. 该药物已经用于管理治疗的副作用,如热闪光等,可以改进坚持性和结果。 The drug, already used to manage treatment side effects like hot flashes, may improve adherence and outcomes. 虽然需要进一步的研究,但结果表明,美格斯特醇可以提供症状缓解和直接抗癌益处. While further research is needed, the results suggest megestrol could offer both symptom relief and direct anti-cancer benefits.