高脂肪饮食重新规划肝细胞, 增加癌症风险, 新的麻省理工学院的研究发现。 High-fat diets reprogram liver cells, increasing cancer risk, a new MIT study finds.

一项新的麻省理工学院研究发现,长期的高脂肪饮食将肝细胞改造成原始、干状状态,增加了肝癌的风险。 A new MIT study finds that long-term high-fat diets reprogram liver cells into a primitive, stem-like state, increasing liver cancer risk. 脂肪超重造成的慢性代谢压力导致细胞放弃新陈代谢和蛋白质生产等正常功能,代之以启动生存机制,使其更容易受到致癌突变的影响。 Chronic metabolic stress from fat overload causes cells to abandon normal functions like metabolism and protein production, instead activating survival mechanisms that make them more vulnerable to cancer-causing mutations. 研究人员在小鼠使用单细胞RNA测序后发现,几乎所有高脂肪膳食喂养的小鼠都患肝癌,关键的转录因子被确定为潜在的治疗目标。 Using single-cell RNA sequencing in mice, researchers observed that nearly all high-fat diet-fed mice developed liver cancer, with key transcription factors identified as potential therapeutic targets. 研究结果解释了为什么脂肪性肝病往往先于肝癌,并突出说明了饮食不良造成的深刻、持久的生物变化。 The findings explain why fatty liver disease often precedes liver cancer and highlight the profound, lasting biological changes caused by poor diet.