研究发现,由于睡眠中断和LILRB4过度活动,与激进乳腺癌有关的轮班工作。 Shift work linked to aggressive breast cancer via disrupted sleep and LILRB4 overactivity, study finds.

一项新的研究将睡眠周期从夜间中断和轮班转至更具攻击性的乳腺癌联系起来,发现环形失调会促进肿瘤生长和动物模型的传播。 A new study links disrupted sleep cycles from night and rotating shifts to more aggressive breast cancer, finding that circadian misalignment promotes tumor growth and spread in animal models. 研究人员发现一个过活性免疫检查站分子LILRB4,抑制了身体抗癌的能力。 Researchers identified an overactive immune checkpoint molecule, LILRB4, which suppresses the body’s ability to fight cancer. 以LILRB4为目标,即使条件中断,也减少了肿瘤的发病,表明可能进行治疗。 Targeting LILRB4 reduced tumor progression even under disrupted conditions, suggesting a potential treatment. 调查结果表明,轮班工作可能积极推动癌症的发展,而不仅仅是增加风险,并强调需要为数百万非正常工作时间的美国人制定保护性战略。 The findings indicate that shift work may actively drive cancer development, not just increase risk, and underscore the need for protective strategies for the millions of Americans working irregular hours.