一项研究发现,由于年龄关系,SIRT6的下降会破坏切除切除切除切除新陈代谢,从而损害大脑健康,但阻止TDO2可能会减少损害。 A study finds SIRT6 decline with age harms brain health by disrupting tryptophan metabolism, but blocking TDO2 may reduce damage.

发表在"自然通讯"杂志上的一项跨国研究显示,SIRT6酶通过调节三甲代谢, 影响能量产生, 血清素和黑素, 帮助保护大脑免受衰老. A multinational study published in Nature Communications reveals that the enzyme SIRT6 helps protect the brain from aging by regulating tryptophan metabolism, which affects energy production, serotonin, and melatonin. 随着SIRT6随着年龄的增长而下降,转基因人转向产生有毒副产品的途径,导致认知下降、睡眠问题和情绪紊乱。 As SIRT6 declines with age, tryptophan shifts toward a pathway producing toxic byproducts, contributing to cognitive decline, sleep issues, and mood disorders. 在缺乏SIRT6的果蝇中,抑制酶TDO2减少脑损伤和改善行动能力,表明针对SIRT6或TDO2可提供与年龄有关的大脑健康问题的新治疗。 In fruit flies lacking SIRT6, inhibiting the enzyme TDO2 reduced brain damage and improved mobility, suggesting that targeting SIRT6 or TDO2 could offer new treatments for age-related brain health problems.