根据UCSF的一项研究,雌激素通过激活结肠细胞、在月经周期期间妇女症状恶化以及可能影响到男子服用某些药物,增加了IBS的肠胃疼痛。 Estrogen heightens gut pain in IBS by activating colon cells, worsening symptoms in women during menstrual cycles and potentially affecting men on certain medications, according to a UCSF study.

加利福尼亚大学旧金山大学在《科学》杂志上发表的一项研究发现,雌激素通过在结肠中激活L细胞、引发过量的PYY释放以及扩大对肠道细菌代谢物的疼痛信号,增加了肠道内肠综合征(IBS)对雌激素的胃痛敏感度。 A University of California, San Francisco study published in Science finds estrogen increases gut pain sensitivity in irritable bowel syndrome (IBS) by activating L-cells in the colon, triggering excess PYY release and amplifying pain signals in response to gut bacteria metabolites. 研究解释了为什么在某些月经阶段,妇女往往经历恶化的IBS症状,以及为什么低FODMAP饮食会帮助一些病人。 The research explains why women often experience worsened IBS symptoms during certain menstrual phases and why low-FODMAP diets help some patients. 雌性激素效应在雄性小鼠体内被复制,因为雌性激素具有女性水平的雌性激素,这表明这条途径在两性中都很活跃,有可能影响到男子服用阻塞雌性激素的药物。 Estrogen’s effect was replicated in male mice given female-level estrogen, suggesting the pathway is active in both sexes, potentially affecting men on androgen-blocking medications. 调查结果显示,治疗IBS的新药物目标超越了饮食限制。 The findings reveal new drug targets for treating IBS beyond dietary restrictions.