根据2025年的一项研究,DNA结构的中断,而不仅仅是突变,通过损害肿瘤抑制基因,可造成血癌。 DNA structure disruptions, not just mutations, can cause blood cancers by impairing tumor suppressor genes, according to a 2025 study.

2025年在美国血液学学会会议上提交的一项研究表明,DNA3D结构的中断,特别是基因调节者与目标连接的循环中断,即使没有重大的基因突变,也可能导致淋巴瘤等血癌。 A 2025 study presented at the American Society of Hematology conference reveals that disruptions in DNA’s 3D structure, particularly the breakdown of loops connecting gene regulators to targets, can lead to blood cancers like lymphoma even without major genetic mutations. 研究人员发现,由于SMC3和CTCF等建筑性蛋白质水平降低,DNA循环变弱,会损害肿瘤抑制基因和免疫细胞发育。 Researchers found that weakened DNA looping due to reduced levels of architectural proteins such as SMC3 and CTCF impairs tumor suppressor genes and immune cell development. 科学家们利用人工智能分析基因组数据, 在癌症发作前发现了早期的结构变化, 引入了“建筑肿瘤抑制”的概念。 Using AI to analyze genomic data, scientists identified early structural changes preceding cancer onset, introducing the concept of "architectural tumor suppression." 在扩散的大型B细胞淋巴瘤患者中,较低的SMC3水平与更坏的结果相关,建议基因组结构可作为未来的生物标志。 Lower SMC3 levels in diffuse large B-cell lymphoma patients correlated with worse outcomes, suggesting genome architecture may serve as a future biomarker. 调查结果突出表明DNA的物理组织是预防癌症的关键因素,为新的诊断和疗法开辟了道路,重点是恢复适当的DNA折叠。 The findings highlight DNA’s physical organization as a key factor in cancer prevention, opening pathways for new diagnostics and therapies focused on restoring proper DNA folding.