一项研究将常见的BK病毒与膀胱癌联系起来,通过免疫系统损伤,即使在病毒消失后也是如此。 A study links the common BK virus to bladder cancer via immune system damage, even after the virus is gone.

约克大学在《科学进步》杂志上发表的一项研究表明,BK病毒在童年常见,通常处于休眠状态,通过人体的免疫反应造成DNA损伤,可能会引发膀胱癌。 A University of York study published in Science Advances suggests the BK virus, common in childhood and usually dormant, may trigger bladder cancer by causing DNA damage through the body’s immune response. 研究人员发现,抗病毒酶攻击病毒,但也伤害附近的健康细胞——一种“旁观者效应”——在癌症中产生突变,即使病毒不再可检测。 Researchers found that antiviral enzymes attack the virus but also harm nearby healthy cells—a "bystander effect"—creating mutations seen in cancer, even when the virus is no longer detectable. 这种由免疫力驱动的损伤可能解释为什么在确诊的病例中往往没有BK病毒。 This immune-driven damage may explain why BK virus is often absent in diagnosed cases. 根据对人类膀胱细胞的实验室分析得出的研究结果表明,早期病毒控制是一项潜在的预防战略,特别是对于诸如移植接受者等高风险群体而言。 The findings, based on lab analysis of human bladder cells, point to early viral control as a potential prevention strategy, especially for high-risk groups like transplant recipients. 计划进行临床试验,以确认这种联系,并探讨如何在病毒造成持久伤害之前针对病毒来降低膀胱癌的风险。 Clinical trials are planned to confirm the link and explore ways to reduce bladder cancer risk by targeting the virus before it causes lasting harm.