吸入的一氧化二氮在50%的水平上可能会迅速缓解抗治疗性抑郁症,24小时内产生影响,但惠益会逐渐消失,不再继续使用。 Inhaled nitrous oxide at 50% may rapidly ease treatment-resistant depression, with effects in 24 hours, but benefits fade without continued use.

伯明翰大学的一项研究发现,吸入的一氧化二氮浓度为50%,可能会迅速减少患有抗治疗性严重抑郁症的成年人的抑郁症状,其影响在24小时内显现,并且从反复治疗中长期受益。 A University of Birmingham study finds inhaled nitrous oxide at 50% concentration may rapidly reduce depressive symptoms in adults with treatment-resistant major depressive disorder, with effects seen within 24 hours and longer-lasting benefits from repeated treatments. 该气体作用于脑中的谷氨酸受体，如氯胺酮，提供了一种快速起效的替代方案，尽管效果通常在无持续治疗一周后减弱。 The gas acts on brain glutamate receptors like ketamine, offering a fast-acting alternative, though benefits typically fade after a week without ongoing therapy. 副作用发生于浓度较高的地方,强调需要控制使用。 Side effects occurred at higher concentrations, emphasizing the need for controlled use. 研究人员正在筹备第一次国民保健制度试验,以评估其长期潜力,同时注意到目前的证据因试验的变异性而受到限制。 Researchers are preparing the first NHS trial to evaluate its long-term potential, noting current evidence is limited by trial variability.