患有积极性口腔癌的南印度妇女表现出与吸烟有关的独特的基因突变,这促使人们呼吁进行针对不同性别的预防和治疗。 Southern Indian women with aggressive oral cancer show unique genetic mutations linked to tobacco use, prompting calls for gender-specific prevention and treatment.

印度研究人员在南部印度妇女中发现了独特的基因突变,这些妇女口腔癌具有攻击性,与在贝特尔顿和古卡咀嚼烟草有关。 Indian researchers have found unique genetic mutations in southern Indian women with aggressive oral cancer, linked to chewing tobacco in betel quid and gutka. 对38名妇女的研究发现,CASP8和TP53基因中的突变率很高,CASP8成为与男性模式不同的潜在驱动因素。 A study of 38 women identified high rates of mutations in CASP8 and TP53 genes, with CASP8 emerging as a potential driver mutation distinct from male patterns. AI分析发现两种肿瘤子型有不同的免疫反应,表明个人化治疗路径。 AI analysis revealed two tumor subtypes with different immune responses, suggesting personalized treatment paths. 另一项大型研究发现,染色体5和6的遗传风险变异物与NOCH1一起,尽管吸烟类似,但导致高风险个人比其他人大约早10年患上癌症。 Another large study found genetic risk variants on chromosomes 5 and 6, along with NOTCH1, that cause high-risk individuals to develop cancer about 10 years earlier than others, despite similar tobacco use. 这些调查结果突出表明遗传易感性是早期出现的一个关键因素,并强调需要针对不同性别的研究、更好的预防和专门针对印度的风险工具。 These findings highlight genetic susceptibility as a key factor in early onset and underscore the need for gender-specific research, better prevention, and Indian-specific risk tools.