UC San Diego 研究人员创造了珊瑚ME,这是一个快速模拟肠胃微生物的工具,揭示饮食如何影响肠胃健康,并将微生物变化与炎症肠道疾病联系起来。 UC San Diego researchers created coralME, a tool that quickly models gut microbes, revealing how diet affects gut health and linking microbial changes to inflammatory bowel disease.

圣地亚哥哥伦比亚大学的研究人员开发了珊瑚生态系统,这是一个新工具,它迅速创建了详细的肠道微生物新陈代谢模型,使科学家能够预测这些生物对养分和饮食的反应。 Researchers at UC San Diego have developed coralME, a new tool that rapidly creates detailed metabolic models of gut microbes, enabling scientists to predict how these organisms respond to nutrients and diets. 该工具生成了495个常见直肠细菌模型,其使用时间为人工方法的一小部分,显示低铁或低锌饮食可能有利于有害的微生物,而某些大型营养素则支持有益的微生物。 The tool generated 495 models of common gut bacteria in a fraction of the time manual methods would take, revealing that low-iron or low-zinc diets may favor harmful microbes, while certain macronutrients support beneficial ones. 应用到炎性肠道疾病(IBD)数据中,珊瑚海洋生态系统发现了肠道化学的变化——例如pH值较高、保护性较低的短链脂肪酸——以及将特定微生物变化与该疾病相联系。 Applied to inflammatory bowel disease (IBD) data, coralME identified shifts in gut chemistry—such as higher pH and lower protective short-chain fatty acids—and linked specific microbial changes to the disease. 研究结果可以改善对综合症和其他微生物相关条件的诊断和个性化治疗。 The findings could improve diagnosis and personalized treatment for IBD and other microbiome-related conditions. 该研究于2025年11月20日在细胞系统中发表。 The study was published on November 20, 2025, in Cell Systems.