一项研究通过酶KHK将酒精上瘾和肝病联系起来,显示小鼠阻塞酒精上瘾和肝病会减少饮酒和肝损伤。 A study links alcohol addiction and liver disease via enzyme KHK, showing blocking it in mice reduced drinking and liver damage.

一项新的自然代谢研究将酒精成瘾和肝病通过酶基多克辛酶(KHK)联系起来,该酶在酒精消费时引发内部果糖生产。 A new study in Nature Metabolism links alcohol addiction and liver disease through the enzyme ketohexokinase (KHK), which triggers internal fructose production when alcohol is consumed. 科罗拉多安舒茨大学的研究人员发现,将KHK阻挡在小鼠体内会减少酒精摄入量,减少与上瘾有关的大脑活动,并防止肝脏损伤,如脂肪积聚、炎症和疤痕。 Researchers at the University of Colorado Anschutz found that blocking KHK in mice reduced alcohol intake, lessened addiction-related brain activity, and prevented liver damage like fat buildup, inflammation, and scarring. 调查结果表明,针对fructose新陈代谢的新陈代谢可能导致对酒精使用紊乱和肝病的新治疗,包括与饮食有关的条件,如MARCLD, 提供多种肝病的共同治疗方法。 The findings suggest targeting fructose metabolism could lead to new treatments for alcohol use disorder and liver disease, including diet-related conditions like MASLD, offering a shared therapeutic approach for multiple liver diseases.