科学家们正在使用改良细菌来瞄准肿瘤、提供治疗和自毁,这在剧烈癌症试验中显示了希望。 Scientists are using modified bacteria to target tumors, deliver treatments, and self-destruct, showing promise in trials for tough cancers.

科学家是像Listeria和Salmonella这样的工程细菌,目的是瞄准固体肿瘤,提供癌症治疗,然后自我毁灭,尽量减少对健康组织的伤害。 Scientists are engineering bacteria like Listeria and Salmonella to target solid tumors, deliver cancer therapies, and self-destruct afterward, minimizing harm to healthy tissue. 这些“活药”利用肿瘤的低氧和薄弱的免疫环境, 在第二阶段试验中表现出希望, 加上免疫疗法或化疗, 治疗难以治疗的癌症, These "living medicines" exploit the tumor’s low oxygen and weak immune environment, showing promise in phase 2 trials when combined with immunotherapies or chemotherapy for hard-to-treat cancers like pancreatic and cervical. 70多项临床试验和500多项研究探索了这一方法,不断努力加强安全、控制细菌行为和防止意外影响。 Over 70 clinical trials and 500 studies have explored this approach, with ongoing efforts to enhance safety, control bacterial behavior, and prevent unintended effects.