在严重脂质紊乱患者中,CRISPR疗法减少了将近一半的坏胆固醇和三甘酸盐,效果超过60天。 A CRISPR therapy reduced bad cholesterol and triglycerides by nearly half in patients with severe lipid disorders, with effects lasting over 60 days.

CRISPR治疗法CTX310,这是针对ANGPTL3基因的一次性基因编辑疗法,将LDL胆固醇切除49%,在对15名严重脂肪紊乱的病人进行的第一阶段试验中将三甘酸酯切除55%。 CRISPR Therapeutics’ CTX310, a one-time gene-editing therapy targeting the ANGPTL3 gene, cut LDL cholesterol by 49% and triglycerides by 55% in a Phase 1 trial of 15 patients with severe lipid disorders. 治疗显示持续影响超过60天,没有与治疗相关的严重副作用。 The treatment showed lasting effects beyond 60 days and no serious side effects linked to the therapy.