麻省理工学院的AMG1541纳米粒子AMG1541提升了MRNA疫苗的功效,小鼠的疫苗剂量增加了100倍,削减了99%,需要人工试验。 MIT's AMG1541 nanoparticle boosts mRNA vaccine effectiveness 100-fold and cuts doses by 99% in mice, with human trials needed.

根据老鼠研究,麻省理工学院开发的一种新的脂质纳米粒子AMG1541, 大大提高了 mRNA疫苗的效力,同时将剂量削减99%。 A new MIT-developed lipid nanoparticle, AMG1541, significantly boosts mRNA vaccine effectiveness while cutting doses by 99%, according to mouse studies. 粒子的循环电离脂,加上酯类,提高了交付效率和生物降解性,加快了清除速度并减少了副作用。 The particle’s cyclic ionizable lipid with ester groups improves delivery efficiency and biodegradability, enabling faster clearance and reduced side effects. 它增加了内分泌脱逃的可能性,使更多的MRNA能够到达细胞。 It enhances endosomal escape, allowing more mRNA to reach cells. 该技术公布在《自然纳米技术》上,可以降低流感、COVID-19和其他MRNA疫苗的成本,并改善这些疫苗的可获得性,尽管人类试验尚待进行。 The technology, published in Nature Nanotechnology, could lower costs and improve accessibility for flu, COVID-19, and other mRNA vaccines, though human trials are pending.