牛津研究人员将DNA的3D结构绘制成基面分辨率图,将遗传变异与疾病联系起来,并推进精密医学。 Oxford researchers map DNA's 3D structure at base-pair resolution, linking genetic variations to diseases and advancing precision medicine.

牛津大学James Davies教授领导的研究人员发表了一项具有里程碑意义的 " 细胞 " 研究,使用一种名为CCC 超强的新技术,用底孔分辨率绘制人体细胞DNA的3D结构图。 Researchers led by Professor James Davies at Oxford University have published a landmark study in Cell, using a new technique called MCC ultra to map the 3D structure of DNA in human cells at base-pair resolution. 该研究揭示了非编码监管要素如何与基因相互作用,揭示了基因变异如何会干扰这些相互作用,并导致诸如自发免疫紊乱、心脏病和癌症等疾病。 The study reveals how non-coding regulatory elements interact with genes, showing how genetic variations can disrupt these interactions and contribute to diseases like autoimmune disorders, heart disease, and cancer. 这些研究结果是由核循环疗法对MCC技术的独家许可所促成的,为将遗传风险变异体与具体的基因电路联系起来、加速发现有针对性的疗法和推进精密医学提供了一种新的途径。 The findings, enabled by Nucleome Therapeutics’ exclusive license to MCC technology, offer a new way to link genetic risk variants to specific gene circuits, accelerating the discovery of targeted therapies and advancing precision medicine.