一项新研究发现,长期使用普通药物如抗生素和苯并二氮杂卓可以永久改变直肠细菌。 Long-term use of common drugs like antibiotics and benzodiazepines can permanently alter gut bacteria, a new study finds.

对2 509名爱沙尼亚成年人进行的一项新研究发现,普通处方药——包括抗生素、抗抑郁剂、PPIs、苯并二氮杂卓和乙型阻塞剂——能够以停止使用后持续数年的方式改变肠内微生物。 A new study of 2,509 Estonian adults finds that common prescription drugs—including antibiotics, antidepressants, PPIs, benzodiazepines, and beta-blockers—can alter the gut microbiome in ways that last years after stopping use. 研究人员将长期药物使用与微生物多样性的持续变化联系起来,其影响随着持续时间和多种药物而恶化。 Researchers linked long-term medication use to persistent changes in microbial diversity, with effects worsening with duration and multiple drugs. 二类药物,尤其是阿尔普拉佐拉姆,显示出强烈的负面影响. Benzodiazepines, especially alprazolam, showed strong negative impacts. 调查结果表明,过去的吸毒情况应在健康评估和微生物研究中加以考虑,强调必须在治疗利益与长期直肠保健之间取得平衡。 The findings suggest past drug use should be considered in health assessments and microbiome research, highlighting the need to balance treatment benefits with long-term gut health.