全球研究发现,尽管遗传变异有限,而且非类型菌株的抗生素抗药性不断增强,但普遍使用H.流感疫苗是可能的。 A global study finds a universal H. influenzae vaccine may be possible despite limited genetic variation and rising antibiotic resistance in non-typeable strains.

一项分析10 000多个流感嗜血杆菌基因组的全球研究显示,尽管遗传交换率很高,但细菌的整体差异有限,表明针对受保护特征的普遍疫苗可能可行。 A global study analyzing over 10,000 Haemophilus influenzae genomes reveals that despite high genetic exchange, the bacterium shows limited overall variation, suggesting a universal vaccine targeting conserved features may be feasible. 在泰国难民营95%以上的肺炎病例中发现了非型H.流感(NTHI),这是儿童肺炎和耳感染的主要原因,并表现出广泛的抗生素抗药性。 Non-typeable H. influenzae (NTHi), a major cause of childhood pneumonia and ear infections, was found in over 95% of pneumonia cases in a Thai refugee camp and exhibits widespread antibiotic resistance. 虽然存在乙型菌株的疫苗,但无法防止NTHi感染,NTHi缺乏有效的疫苗。 While a vaccine exists for the type b strain, it does not protect against NTHi, which lacks an effective vaccine. 调查结果支持开展紧急努力,开发广谱疫苗,改进全球监测,特别是在资源贫乏的情况下。 The findings support urgent efforts to develop a broad-spectrum vaccine and improve global surveillance, especially in low-resource settings.