科学家发现100个阿尔茨海默氏病的风险基因会影响果蝇的大脑健康, Scientists found 100 Alzheimer’s risk genes affect brain health in fruit flies, revealing key pathways linked to the disease.

科学家利用果蝇研究100种人类阿尔茨海默氏病的风险基因,发现许多人在成人大脑中活跃,对于神经功能、应激反应和对有毒蛋白质的抗御能力至关重要。 Scientists used fruit flies to study 100 human Alzheimer’s risk genes, finding many are active in adult brains and crucial for neuron function, stress response, and resilience to toxic proteins. 关闭18个基因导致神经衰竭,而35个对正常神经活动至关重要,8个对压力恢复至关重要。 Turning off 18 genes caused neurodegeneration, while 35 were vital for normal neuron activity and eight for stress recovery. 28 个基因影响对淀粉样蛋白-β 和 tau 蛋白的反应。 Twenty-eight genes influenced responses to amyloid-beta and tau. 这项研究由Baylor医学院和得克萨斯儿童医院牵头,揭示了阿尔茨海默氏病背后的各种生物途径,解释了症状和治疗的多变性。 The research, led by Baylor College of Medicine and Texas Children’s Hospital, reveals diverse biological pathways may underlie Alzheimer’s, explaining symptom and treatment variability. 调查结果通过公共数据门户 " ALICE " 共享。 Findings are shared via ALICE, a public data portal.