一项新的研究发现13个基因,包括5个新基因,与全球各保留地的严重肥胖症有关。 A new study finds 13 genes, including five new ones, linked to severe obesity across global ancestries.

2025年10月30日《自然通讯》发表的一份新研究报告指出,全球六大保留地有13种与肥胖有关的基因,其中包括5种新发现的基因——YLPM1、RIF1、GIGYF1、SLC5A3和GRM7——每一种基因都使严重的肥胖风险增加大约三倍。 A new study published in Nature Communications on October 30, 2025, identifies 13 genes linked to obesity across six major global ancestries, including five newly discovered ones—YLPM1, RIF1, GIGYF1, SLC5A3, and GRM7—that each increase severe obesity risk by about threefold. 研究人员利用来自英国生物库和NIH的All of Us Research Programme的85万成年人的数据,发现稀有基因变异会扰乱基因功能,特别是脑和脂肪组织中的基因功能,与肥胖症和类似2型糖尿病和心脏衰竭等相关条件密切相关。 Using data from 850,000 adults across diverse populations from the UK Biobank and NIH’s All of Us Research Program, researchers found rare genetic variants disrupting gene function, particularly in brain and fat tissue, with strong ties to obesity and related conditions like type 2 diabetes and heart failure. 研究结果突出表明,需要开展包容性遗传研究,以发现全球相关基因和先进精密医学。 The findings underscore the need for inclusive genetic research to uncover globally relevant genes and advance precision medicine.