UConn研究人员利用CRISPR创建了快速、廉价的血液测试,以在几分钟内从微子RNA中检测早期阿尔茨海默氏病症状。 UConn researchers created fast, cheap blood tests using CRISPR to detect early Alzheimer’s signs from microRNA in minutes.

康涅狄格大学的研究人员利用CRISPR-Cas13A技术开发了两项快速、低成本的血液测试,通过在血液样本中确定具体的微RNA生物标志,检测阿尔茨海默氏病的早期症状。 Researchers at the University of Connecticut have developed two rapid, low-cost blood tests using CRISPR-Cas13A technology to detect early signs of Alzheimer’s disease by identifying specific microRNA biomarkers in blood samples. 这些测试可以在几分钟内产生结果,使用3D打印的96well托盘固定检测部件,并在阿尔茨海默氏病相关RNA出现时产生可见信号。 The tests, which can deliver results in minutes, use a 3D-printed 96-well tray to anchor detection components and produce visible signals when Alzheimer’s-related RNA is present. 其中一个版本检测到一个生物标志,而另一个版本同时分析三个,并计划做出一个综合分析。 One version detects a single biomarker, while another analyzes three simultaneously, with plans to create a comprehensive assay. 这项技术仍在开发之中,能够在出现症状之前的几年内进行早期诊断,从而有可能改变病人的护理。 The technology, still in development, could enable early diagnosis years before symptoms appear, potentially transforming patient care. 研究人员的目的是通过与UConn健康中心老龄化中心合作,用更多的病人样本来验证测试结果。 Researchers aim to validate the tests with more patient samples through collaboration with UConn Health’s Center on Aging.