科学家在土壤细菌中发现了一种强大的抗生素中间体,可以对抗抗药性感染,而不会引发抗药性。 Scientists found a potent antibiotic intermediate in soil bacteria that fights drug-resistant infections without triggering resistance.

来自Warwick大学和Monash大学的化学家已经发现了甲基氮素C lactone(甲基氮素A的生物合成中间体),它比其母体化合物(如MRSA和VRE)对抗药性抗淋巴阳性细菌(如MRSA和VRE)的效力高100倍以上。 Chemists from the University of Warwick and Monash University have discovered pre-methylenomycin C lactone, a biosynthetic intermediate of methylenomycin A, which is over 100 times more effective than its parent compound against drug-resistant Gram-positive bacteria like MRSA and VRE. 与vancomycin不同,该化合物在测试期间没有出现可检测的抗药性发育,在Streptomysces coelicolor发现,这表明自然可能会产生作为中间体的强效抗生素。 The compound showed no detectable resistance development during testing, unlike vancomycin, and was found in Streptomyces coelicolor, suggesting nature may produce potent antibiotics as intermediates. 已经开发了一个可缩放的合成方法,以便能够进行进一步研究。 A scalable synthesis method has been developed, enabling further study. 这一发现在抗微生物抗药性不断上升的情况下,为抗生素发展提供了新的战略,抗微生物抗药性上升是对全球健康的重大威胁。 The discovery offers a new strategy for antibiotic development amid rising antimicrobial resistance, a major global health threat.