科学家创造了合成T细胞受体,更有效地针对小鼠的固态肿瘤,提高存活率。 Scientists created synthetic T-cell receptors that target solid tumors more effectively in mice, improving survival.

EPFL和UNIL-CHUV的研究人员开发了一个计算平台,设计名为T-SenSER的合成蛋白受体,帮助T细胞更好地瞄准固态肿瘤。 Researchers at EPFL and UNIL-CHUV have developed a computational platform to design synthetic protein receptors called T-SenSERs that help T cells better target solid tumors. 这些受体检测到肿瘤微环境中的具体信号,如VEGF或CSF1,只有当有这些信号时才激活T细胞。 These receptors detect specific signals in the tumor microenvironment, such as VEGF or CSF1, and activate T cells only when those signals are present. 在肺癌和多种骨髓瘤的老鼠模型中,T-SenSERs与CAR-T细胞相结合,改善了肿瘤的控制和存活。 In mouse models of lung cancer and multiple myeloma, combining T-SenSERs with CAR-T cells improved tumor control and survival. 该平台能够进行精确、可定制的受体设计,为加强癌症免疫疗法的安全和有效性提供了新方法。 The platform enables precise, customizable receptor design, offering a new way to enhance the safety and effectiveness of cancer immunotherapies. 研究结果发表在《自然生物医学工程》上。 The findings were published in Nature Biomedical Engineering.