一项新的研究显示,ALS运动神经元由于高代谢压力和超负荷蛋白清理系统而退化。 A new study shows ALS motor neurons degenerate due to high metabolic stress and overwhelmed protein cleanup systems.

2025年10月27日发表的一份新研究报告显示,ALS的大型运动神经元面临慢性内部压力,原因是新陈代谢需求高,蛋白质和器官不断清洁,严重依赖自发和蛋白质的演化反应。 A new study published on October 27, 2025, reveals that large motor neurons in ALS face chronic internal stress due to high metabolic demands and constant protein and organelle cleanup, relying heavily on autophagy and the unfolded protein response. 与大多数ALS案例有关的TDP-43的损失最初支持神经功能,但最终压倒了这些保护系统。 The loss of TDP-43, linked to most ALS cases, initially supports neuron function but eventually overwhelms these protective systems. 研究人员利用斑马鱼模型发现,这种由细胞大小和能量需求驱动的内在负担使得运动神经元特别脆弱,解释了其选择性衰减的原因。 Using zebrafish models, researchers found this intrinsic burden, driven by cell size and energy needs, makes motor neurons uniquely vulnerable, explaining their selective degeneration. 研究结果指出,降低细胞退化压力是一种潜在的治疗战略。 The findings point to reducing cellular degradation pressure as a potential treatment strategy.