2025 年的一项研究将第一代抗组胺药与老年住院成人谵妄风险增加 41% 联系起来，敦促采取更安全的替代品。 A 2025 study links first-gen antihistamines to a 41% higher delirium risk in older hospitalized adults, urging safer alternatives.

2025 年对加拿大安大略省超过 328,000 名住院老年人进行的一项研究发现，经常开苯海拉明等第一代抗组胺药的医生入院的患者患谵妄的风险要高出 41%。 A 2025 study of over 328,000 older adults hospitalized in Ontario, Canada, finds that patients admitted to physicians who frequently prescribe first-generation antihistamines like diphenhydramine face a 41% higher risk of developing delirium. 这项研究发表在"美国老年病学学会杂志"上,分析了2015年至2022年的数据,发现狂妄症发生在34.8%的病例中. The research, published in the Journal of the American Geriatrics Society, analyzed data from 2015 to 2022 and found delirium occurred in 34.8% of cases. 这些药物虽然用于过敏和睡眠,但与老年人的镇静和认知障碍有关。 These medications, while used for allergies and sleep, are linked to sedation and cognitive impairment in older adults. 研究人员敦促医院医生限制使用和考虑更安全的替代品,支持更新准则,以劝阻老年人例行使用。 Researchers urge hospital doctors to limit use and consider safer alternatives, supporting updated guidelines that discourage routine use in seniors.