一项重大研究发现,30种抗抑郁剂之间有着显著的副作用差异,其问题较少,有些则造成体重增加或心脏变化。 A major study finds significant side effect differences among 30 antidepressants, with SSRIs having fewer issues and some causing weight gain or heart changes.

一项大型的“柳叶刀”研究分析了来自58 000多人的数据,发现在前八周内,30种抗抑郁药在物理副作用方面有显著差异,包括体重变化、心率变化和血压变化。 A large Lancet study analyzing data from over 58,000 people finds significant differences in physical side effects among 30 antidepressants, including weight changes, heart rate shifts, and blood pressure variations within the first eight weeks. 像塞特拉林和利这样的SSRI的副作用较少,而阿米和利等药物与显著的体重增加有关,而其他如诺特类药物则增加了心率和血压. SSRIs like sertraline and citalopram showed fewer side effects, while drugs such as amitriptyline and maprotiline were linked to substantial weight gain, and others like nortriptyline increased heart rate and blood pressure. Agomelatine与体重损失有关。 Agomelatine was associated with weight loss. 调查结果支持个人化处方,特别是针对心脏病患者或新陈代谢患者,并呼吁共同决策和例行监测。 The findings support personalized prescribing, especially for those with heart disease or metabolic conditions, and call for shared decision-making and routine monitoring. 8周之后的长期影响仍不清楚,研究人员敦促更新准则,以改善治疗安全和合规。 Long-term effects beyond eight weeks remain unclear, and researchers urge updated guidelines to improve treatment safety and adherence.