加州大学洛杉矶分校的一项研究发现,妇女X染色体上的Kdm6a基因会引发更高的大脑炎,增加阿尔茨海默氏病和其他病症的风险。 A UCLA study finds the Kdm6a gene on women’s X chromosomes drives higher brain inflammation, increasing risk for Alzheimer’s and other conditions.

加州大学洛杉矶分校的一项研究将X染色体上的Kdm6a基因确定为妇女大脑发炎加剧的一个关键因素,解释了她们患老年痴呆症、多发性硬化症和更年期脑雾的风险增加的原因。 A UCLA study identifies the Kdm6a gene on the X chromosome as a key factor in higher brain inflammation in women, explaining their increased risk for Alzheimer’s, multiple sclerosis, and menopausal brain fog. 妇女的两个X染色体导致双重剂量的基因,导致微小lia的炎症发作。 Women’s two X chromosomes result in a double dose of the gene, driving inflammation in microglia. 在雌性小鼠体内,关闭Kdm6a或使用美同体可减少炎症和症状,而更年期雌激素下降可消除保护效应。 In female mice, turning off Kdm6a or using metformin reduced inflammation and symptoms, while estrogen decline during menopause may remove protective effects. 研究结果发表在《科学翻译医学》上,突显了基于性别的生物差异,并指出了潜在的治疗方法,如针对大脑的雌激素治疗。 The findings, published in Science Translational Medicine, highlight sex-based biological differences and point to potential treatments like brain-specific estrogen therapies.