Mira-55, 一种非类尿大麻类比, 减少动物的疼痛和肿胀而没有镇静剂, 在早期测试中比吗啡要好。 Mira-55, a non-opioid marijuana analog, reduced pain and swelling in animals without sedation, outperforming morphine in early tests.

MIRA制药公司报告说,口服Mira-55口服的吗啡在减少炎痛动物模式中的疼痛和炎症、完全恢复疼痛阈值和大幅度降低肿胀方面表现优于注射吗啡。 MIRA Pharmaceuticals reported that oral Mira-55 outperformed injected morphine in reducing pain and inflammation in an animal model of inflammatory pain, fully restoring pain thresholds and significantly decreasing swelling. 该化合物是CB2受体选择性大麻类比,可提供直接的抗炎效果和减轻疼痛,无镇静剂或阿片风险。 The compound, a CB2 receptor-selective analog of marijuana, provided direct anti-inflammatory effects and pain relief without sedation or opioid risks. 这些临床初步结果支持了MIRA计划对慢性炎痛的IND应用,这一疾病影响数百万人,目前使用类阿片或非阿片或非阿片药物进行治疗,两者都引起安全关切。 These preclinical results support MIRA’s planned IND application for chronic inflammatory pain, a condition affecting millions and currently treated with opioids or NSAIDs, both of which carry safety concerns. 在全球市场的不断增长中,Mira-55的双重机制提供了非阿片类药物,非NSAID替代品的潜力. Mira-55’s dual mechanism offers potential as a non-opioid, non-NSAID alternative in a growing global market.