中国科学家发现,在裸体摩尔鼠体内,具体的CGAS突变加强了DNA的修复、延长寿命和减少动物的老化迹象,为人类长寿提供了一条可能的途径。 Chinese scientists found that specific cGAS mutations in naked mole-rats enhance DNA repair, extending lifespan and reducing aging signs in animals, suggesting a potential path for human longevity.

中国科学家发现,裸体内鼠的CGAS酶中的四种具体突变促进了DNA的修复,有助于其40年的寿命。 Chinese scientists have discovered that four specific mutations in the naked mole-rat’s cGAS enzyme boost DNA repair, contributing to its 40-year lifespan. 与人类和小鼠不同的是,CGAS阻碍修理,而内鼠的版本强化了它,改善了基因组稳定性。 Unlike in humans and mice, where cGAS hinders repair, the mole-rat’s version enhances it, improving genomic stability. 实验显示,经过改良的酶的水果苍蝇活得更长,并且更加活跃,而小鼠则在短短两个月的时间里显示出老化迹象的减少。 Experiments showed fruit flies with the modified enzyme lived longer and stayed more active, while mice showed reduced aging signs in just two months. 另外两个长寿命的鼠类也存在类似的突变。 Similar mutations exist in two other long-lived rodents. 研究人员说,以CGAS为目标可以提供一种新的战略,通过改进DNA修复和减少炎症来延长健康的人类寿命。 Researchers say targeting cGAS could offer a new strategy for extending healthy human lifespan by improving DNA repair and reducing inflammation.