一个新的脱氧核糖核酸工具揭示了老化、吸烟和戒酒的遗传痕迹,健康组织中的突变暗示着未来的癌症风险。 A new DNA tool reveals aging, smoking, and alcohol leave genetic marks, with mutations in healthy tissue hinting at future cancer risk.

一个新的DNA测序工具叫作目标NanoSeq,使研究人员能够以高精度探测健康组织中的稀有突变,揭示出老龄化、吸烟和酒精使用留下不同的遗传特征。 A new DNA sequencing tool called targeted NanoSeq has enabled researchers to detect rare mutations in healthy tissues with high accuracy, revealing that aging, smoking, and alcohol use leave distinct genetic signatures. 在对1,000多人进行的一项研究中,科学家发现了数十万次突变,包括与癌症有关的基因数以万计,一些突变显示出增长优势的迹象。 In a study of over 1,000 people, scientists identified hundreds of thousands of mutations, including tens of thousands in cancer-related genes, with some mutations showing signs of growth advantage. 虽然大多数变异细胞克隆体仍然小而稳定,但调查结果表明,这些变化可作为癌症风险的早期指标。 While most mutant cell clones remain small and stable, the findings suggest these changes could serve as early indicators of cancer risk. 这一技术还发现,精子的有害突变随着父亲年龄的增长而增加,使人们对遗传遗传风险产生担忧。 The technique also found that harmful mutations in sperm increase with paternal age, raising concerns about inherited genetic risks. 该方法目前在研究中广泛使用,可能有助于预测癌症风险和改进预防战略。 The method, now widely used in research, may help predict cancer risk and improve prevention strategies.