研究发现，胶质母细胞瘤会侵蚀颅骨并破坏免疫力，这揭示了当前治疗的局限性。 Glioblastoma erodes skull bones and disrupts immunity, study finds, revealing limitations of current treatments.

根据蒙特菲奥·爱因斯坦研究人员的一项研究,Glioblastoma是最致命的脑癌,导致头骨腐蚀,并改变了头骨骨髓的免疫活动。 Glioblastoma, the deadliest brain cancer, causes skull bone erosion and alters immune activity in skull marrow, according to a study by Montefiore Einstein researchers. 小鼠和人体CT扫描中的高级成像显示肿瘤侵蚀头骨缝,扩大骨管,促进炎症,同时抑制其他骨骼如股骨的免疫细胞生产。 Advanced imaging in mice and human CT scans show tumors erode skull sutures and expand bone channels, promoting inflammation while suppressing immune cell production in other bones like the femur. 由林业发展局批准的骨质疏松药物抑制了头骨损伤,但使一类肿瘤生长恶化,阻断了抗DP-L1免疫疗法。 FDA-approved osteoporosis drugs halted skull damage but worsened tumor growth in one type and blocked anti-PD-L1 immunotherapy. 调查结果显示,目前的治疗失败了,因为它们忽视了癌症的系统性影响,表明需要针对肿瘤对骨骼和免疫力的更广泛影响制定新的治疗方法。 The findings suggest current treatments fail because they ignore the cancer’s systemic effects, pointing to the need for new therapies targeting the tumor’s broader impact on bone and immunity.