一项新的研究发现,ALS与对神经的免疫攻击有关,免疫反应影响疾病发展。 A new study finds ALS is linked to immune attacks on nerves, with immune responses affecting disease progression.

一项新的研究将ALS与自动免疫活动联系起来,发现有些病人的CD4+T细胞在神经中攻击C9orf72蛋白质,引发炎症和神经损伤。 A new study links ALS to autoimmune activity, finding that CD4+ T cells in some patients attack the C9orf72 protein in nerves, triggering inflammation and nerve damage. 研究人员确定了两个病人群体:迅速发展的人有强烈的煽动性反应,而寿命较长的病人有较高水平的保护性防炎T细胞。 Researchers identified two patient groups: those with rapid progression had strong inflammatory responses, while longer-surviving patients had higher levels of protective anti-inflammatory T cells. 这些结果发表在《自然》上,表明免疫系统调节可能减缓ALS的进化,并可能适用于其他神经退化性疾病。 The findings, published in Nature, suggest immune system modulation could slow ALS progression and may apply to other neurodegenerative diseases. 每年约有5 000名美国人被诊断,大多数存活14至18个月。 About 5,000 Americans are diagnosed annually, with most surviving 14 to 18 months.