与中华裔阿尔茨海默氏更高风险相关的遗传变异,特别是APOE-4加速了脑损伤和认知下降。 A genetic variant linked to higher Alzheimer’s risk in ethnic Chinese, especially with APOE-ε4, accelerates brain damage and cognitive decline.

HKUST研究发现一种基因变异物TREM2 H157Y,它大大增加了中国裔阿尔茨海默氏症的风险,其影响类似于APOE-4。 A HKUST study identifies a genetic variant, TREM2 H157Y, that greatly increases Alzheimer’s risk in ethnic Chinese, with effects similar to APOE-ε4. 它加速了认知下降和大脑损伤, 特别是当与APOE-4结合时。 Found in about 1 in 200 Chinese with AD, it accelerates cognitive decline and brain damage, especially when combined with APOE-ε4. 这项研究以香港环发中心生物库为基础,揭示了免疫、血管和与骨骼有关的生物标志中断,突出表明需要进行多种遗传研究和采取个性化的预防和治疗方法。 The research, based on the HKCeND Biobank, reveals immune, vascular, and bone-related biomarker disruptions, highlighting the need for diverse genetic studies and personalized approaches to prevention and treatment.