GABARAPL1 基因疗法通过增强淋巴法作用,扭转了小鼠和人类心脏组织中的糖尿病心脏衰竭。 淋巴法过程从心细胞中清除了过多的甘油。 Gene therapy boosting GABARAPL1 reversed diabetic heart failure in mice and human heart tissue by enhancing glycophagy, a process that clears excess glycogen from heart cells.

科学家们用基因疗法治疗小鼠和实验室培养的人类心脏组织的糖尿病心力衰竭, Scientists reversed diabetic heart failure in mice and lab-grown human heart tissue using gene therapy that boosts the protein GABARAPL1, essential for a newly discovered process called glycophagy, which clears excess glycogen from heart cells. 治疗恢复了心脏功能,不影响血糖或体重,改善了人体细胞的心脏放松,在女性心脏中表现出了更强烈的效果。 The treatment restored heart function without affecting blood sugar or weight, improved heart relaxation in human cells, and showed stronger effects in female hearts. 研究者认为这直接针对心脏的能源回收, 为糖尿病心脏病提供新的治疗途径。 Researchers say this targets the heart’s energy recycling directly, offering a new treatment path for diabetic heart disease. 这项研究由奥克兰大学和墨尔本大学的小组牵头,由新西兰、澳大利亚、美国和澳大利亚糖尿病组织提供资金。 The study was led by teams from the University of Auckland and University of Melbourne, with funding from organizations in New Zealand, Australia, the U.S., and Diabetes Australia.