科学家使用一种新的成像方法来观察帕金森人的大脑中的阿尔法-核核素寡头,发现一种与该疾病有关的独特形式。 Scientists used a new imaging method to see alpha-synuclein oligomers in Parkinson’s brains, finding a unique form linked to the disease.

科学家开发了一种新的成像技术 -- -- ASA-PD,使人类大脑组织中与帕金森氏病有关的阿尔法-synuclein oligomers-tiny蛋白质群得以首次直接直观地看到阿尔法-synuclein oligomers-tiny 蛋白质团群。 Scientists have developed a new imaging technique, ASA-PD, enabling the first direct visualization of alpha-synuclein oligomers—tiny protein clusters linked to Parkinson’s—in human brain tissue. 研究人员利用超敏感荧光显微镜,在尸检样本中检测到这些以前隐形的寡头,发现它们在帕金森人的大脑中更加丰富和独特。 Using ultra-sensitive fluorescence microscopy, researchers detected these previously invisible oligomers in post-mortem samples, finding them more abundant and distinct in Parkinson’s brains. 仅在病人身上发现了一个先前不为人知的子类,表明可能存在早期疾病标记。 A previously unseen sub-class was found only in patients, suggesting potential early disease markers. 这项突破发表在《自然生物医学工程》上,在主要研究组织的支持下以及病人和家庭的贡献下,可导致早期诊断和新治疗。 The breakthrough, published in Nature Biomedical Engineering, could lead to earlier diagnosis and new treatments, with support from major research organizations and contributions from patients and families.